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84605-18-5

  • Product Name:Cycloastragenol
  • Molecular Formula:C30H50O5
  • Molecular Weight:490.724
  • Appearance:Colorless needle crystal
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Product Details

Appearance:Colorless needle crystal

Purity:99%

Factory Supply Hot Sale 84605-18-5 Cycloastragenol with Safe Transportation

  • Molecular Formula:C30H50O5
  • Molecular Weight:490.724
  • Appearance/Colour:Colorless needle crystal 
  • Vapor Pressure:8.17E-18mmHg at 25°C 
  • Refractive Index:1.582 
  • Boiling Point:617.2 °C at 760 mmHg 
  • PKA:14.57±0.29(Predicted) 
  • Flash Point:327.1 °C 
  • PSA：90.15000 
  • Density:1.2 g/cm3 
  • LogP:4.43660 

Cycloastragenol(Cas 84605-18-5) Usage

Description

Cycloastragenol is a triterpenoid isolated from various legume species in the genus Astragalus that is purported to have telomerase activation activity. TA-65 is capable to increase average telomere length and to decrease the percentage of critically short telomeres and DNA damage in MEFs that harbor critically short telomeres. The effects on telomerase appear to be in common with other triterpenoid saponins (ie, ginsenosides RG1 and Rg3). These compounds at concentrations from 1 to 20 μM were reported to protect against IL-1β-, H2O2-, and tert-butylhydroperoxide-induced senescence in human chondrocytes, endothelial progenitor cells and fibroblasts, respectively.

Uses

Cycloastragenol is an aglycone derivative of astragaloside IV found in the root of Korean Astragalus membranaceus.

Definition

ChEBI: A sapogenin that is the aglycone derivative of astragaloside IV, a major saponin extracted from the root of Astragalus membranaceus.

InChI:InChI=1/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21+,22?,23?,26+,27-,28-,29?,30?/m0/s1

84605-18-5 Relevant articles

Structure of cyclochivinoside C from Astragalus chivensis

Naubeev,Uteniyazov

, p. 560 - 562 (2007)

The new cycloartane glycoside cyclochivi...

Cycloascauloside a from Astragalus caucasicus leaves

Alaniya,Chkadua,Gigoshvili,Kemertelidze

, p. 445 - 448 (2006)

The new cycloartane glycoside cycloascau...

The use of two-phase acid hydrolysis method of preparing ring [...] (by machine translation)

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Paragraph 0024-0066, (2019/07/08)

The invention belongs to the field of ph...

Compositions and methods for skin conditioning

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Page/Page column 21, (2016/02/26)

Methods and cosmetic compositions for co...

Triterpene glycosides from astragalus. Structure of cyclolehmanoside C from A. lehmannianus

Zhanibekov,Naubeev,Uteniyazov,Bobakulov, Kh. M.,Abdullaev

, p. 475 - 477 (2013/09/02)

The structure of a new cycloartane trite...

Flavonoid and cycloartane glycosides from seeds of Koelreuteria paniculata

Sutiashvili,Alaniya,Mshvildadze,Skhirtladze,Pichette,Lavoie

, p. 395 - 397 (2013/07/26)

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84605-18-5 Process route

20S,24R-epoxycycloartan-3,6,16,25-tetraol-3-O-β-D-(2'-O-acetyl)xylopyranosyl-6-O-β-D-xylopyranoside
84883-00-1

20S,24R-epoxycycloartan-3,6,16,25-tetraol-3-O-β-D-(2'-O-acetyl)xylopyranosyl-6-O-β-D-xylopyranoside

D-xylose
58-86-6

D-xylose

20(S),24(R)-epoxy-9β,19-cyclolanostan-3β,6α,16β,25-tetrol
84605-18-5

20(S),24(R)-epoxy-9β,19-cyclolanostan-3β,6α,16β,25-tetrol

Conditions
Conditions Yield
Acidic conditions;
 
astragaloside IV
83207-58-3,84687-43-4

astragaloside IV

cycloastragenol
84605-18-5,90865-25-1,104112-00-7,78574-94-4

cycloastragenol

Conditions
Conditions Yield
With hydrogenchloride; In methanol; at 20 ℃; for 168h;
64%
With hydrogenchloride; In methanol; at 20 ℃; for 168h;
64%
With hydrogenchloride; In ethanol; benzene; for 24h; Heating;
30 mg
With sulfuric acid; In methanol; for 3h;
30 mg
Multi-step reaction with 2 steps
1: 47 mg / H2SO4 / methanol / 4 h / Heating
2: 17 mg / H2SO4 / methanol / 4 h / Heating
With sulfuric acid; In methanol;
 
Multi-step reaction with 2 steps
1: 58 mg / H2SO4 / methanol / 4 h / Heating
2: 11 mg / H2SO4 / methanol; H2O / 4 h / Heating
With sulfuric acid; In methanol; water;
 
With water; Acidic conditions;
 
astragaloside IV; With sodium periodate; In methanol; water; at 20 ℃;
With sodium tetrahydroborate; In methanol; at 20 ℃; for 24h;
With sulfuric acid; In methanol; water; for 24h; pH=2;
384 mg
With hydrogenchloride; In methanol; chloroform; water; at 20 ℃; for 144h; Concentration;
 

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